Lecture of Milan Stojanović, SASA Foreign Member

Professor Milan Stojanović, PhD, a professor at Columbia University and SASA foreign member, will give a lecture titled ’Aptamer Receptors, How, Why and a Little Something on Free Energy Binding’, at the SASA Grand Hall, on Wednesday, 12 October, at noon.

Oligonucleotide-based receptors or aptamers of small molecules have a unique potential in some areas of clinical chemistry because they are able to signalize almost momentous changes in the concentration of critical molecules. To understand how to isolate aptamers with desirable properties (for example to be high-affinity and selective), we have isolated (selected) 26 aptamer receptors for amino acids, analogue amines and amides. The interaction comparisons with ligand couples of these aptamers, enable us to attribute particular contributions to the strength of small molecules binding with appropriate receptors to individual function groups, as well as to identify specific barriers to successful aptamer isolation. This approach has facilitated the isolation of new aptamers, even in situations where previously we had difficulties.

A SASA Foreign Member Milan Stojanović is a full professor at Columbia University, (Department of Biomedical Engineering and Department of Systems Biology). He works on the application of oligonucleotides in medicine. He graduated in chemistry from the Faculty of Natural Sciences and Mathematics in Belgrade. He was elected a foreign member in 2015.

A live broadcast is available at https://www.sanu.ac.rs/direktan-prenos/.